There are several flights from Rome to Pantelleria, on Monday, Friday, Saturday and Sunday.
Starting from 15th June to 15th September Alitalia airline connects Rome to Pantelleria with direct flights, every Saturday and Sunday. It keeps just 1 hour and 15 minutes.
From Rome airport takes off also the low-cost airline Blue Panorama; during summertime, starting from 12nd July until 7th September, it connects Rome to Pantelleria every Monday and Friday morning. It keeps just 1 hour and 20 minutes.